Tumor necrosis factor-alpha (TNF-α) in spotted halibut <italic style="font-style: italic">Verasper variegatus</italic> at the embryonic and metamorphic stages

Zan LI; Xiumei LIU; Xinxin DU; Kai ZHANG; Yan CHEN; Xubo WANG; Zhigang WANG; Haiyang YU; Quanqi ZHANG

doi:10.1007/s00343-019-8289-4

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Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages

Biology | Updated：2023-04-27

- Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages
- Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages
- 海洋湖沼学报（英文） 2020年38卷第2期页码：454-466
- Affiliations：
  
  1.School of Agriculture, Ludong University, Yantai 264025, China
  2.College of Life Sciences, Yantai University, Yantai 264005, China
  3.Key Laboratory of Marine Genetics and Breeding, Ministry of Education, College of Marine Life Science, Ocean University of China, Qingdao 266003, China
- Author bio：
  
  LI Zan, lizanlxm@163.com
- Funds：
  
  the National High Technology Research and Development Program of China (863 Program)(31101891);the Hitech Research and Development Program of China(2012AA10A408);© Chinese Society for Oceanology and Limnology, Science Press, and Springer-Verlag Berlin Heidelberg 2020
- DOI：10.1007/s00343-019-8289-4
  中图分类号：
- 收稿：2018-11-08，
  
  录用：2019-1-28，
  
  网络首发：2019-06-30，
  
  纸质出版：2020-02
- Accepted：
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Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages[J]. 海洋湖沼学报（英文）, 2020,38(2):454-466.

Zan LI, Xiumei LIU, Xinxin DU, et al. Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages[J]. Journal of Oceanology and Limnology, 2020, 38(2): 454-466.
Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages[J]. 海洋湖沼学报（英文）, 2020,38(2):454-466. DOI： 10.1007/s00343-019-8289-4.

Zan LI, Xiumei LIU, Xinxin DU, et al. Tumor necrosis factor-alpha (TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages[J]. Journal of Oceanology and Limnology, 2020, 38(2): 454-466. DOI： 10.1007/s00343-019-8289-4.

摘要

Abstract

As an aquatic fish

the spotted halibut

Verasper variegatus

is highly susceptible to bacterial and virus infections. Tumor necrosis factor-alpha (TNF-α) as a cytokine could control the inflammatory responses. The functions of TNF-α in many species have been widely studied

particularly in mammals. However

little is known about the TNF-α functions in

V. variegatus

. We first cloned and sequenced the TNF-α gene in

V. variegatus

(VvTNF-α). The two conserved cysteine residues

transmembrane sequence

Thr-Leu motif

and TNF family signature

as well as the TA-rich motifs of its proteins related to inflammatory responses had high similarity to those of the other teleost and mammalian TNF-α. The phylogenetic analysis showed that VvTNF-α was consistent with TNF-α genes of other vertebrates. The VvTNF-α transcripts were extensively distributed in the peripheral blood leukocytes (PBLs)

spleen

and gill

indicating that the VvTNF-α had a role in immune function. Furthermore

treatment with pathogen-associated molecular patterns (PAMPs) could induce a rapid and significant increase of VvTNF-α in the PBLs

which reveals that VvTNF-α does participate in the host immune responses against bacterial and viral pathogens. We found that VvTNF-α had an interesting expression pattern during metamorphosis

showing that the flatfish TNF-α may have some novel functions during specific developmental stages. In addition

the 3D structure prediction of VvTNF-α provided an indication of how it is likely to interact with other proteins. Therefore

VvTNF-α has multiple functions

and provides valuable information to explore novel functions of TNF-α.

关键词

Keywords

references

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DOI：10.1007/s00343-019-8289-4

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