Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway

Qi LIU; Wenjun LI; Lina LU; Bin LIU; Zhenning DU; Song QIN

doi:10.1007/s00343-019-8196-8

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Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway

Biology | Updated：2023-05-20

- Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway
- Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway
- 海洋湖沼学报（英文） 2019年37卷第5期页码：1678-1685
- Affiliations：
  
  1.Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
  2.School of Pharmacy, Yantai University, Yantai 264005, China
  3.School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China
- Author bio：
  
  DU Zhenning, zhenning.du@163.com
  QIN Song, sqin@yic.an.cn
- Funds：
  
  the National Key Research and Development Program of China(2018YFD0901102)
- DOI：10.1007/s00343-019-8196-8
  中图分类号：
- 收稿：2018-08-15，
  
  录用：2018-11-10，
  
  网络首发：2019-01-03，
  
  纸质出版：2019-09
- Accepted：
Scan QR Code
Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway[J]. 海洋湖沼学报（英文）, 2019,37(5):1678-1685.

Qi LIU, Wenjun LI, Lina LU, et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway[J]. Journal of Oceanology and Limnology, 2019, 37(5): 1678-1685.
Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway[J]. 海洋湖沼学报（英文）, 2019,37(5):1678-1685. DOI： 10.1007/s00343-019-8196-8.

Qi LIU, Wenjun LI, Lina LU, et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway[J]. Journal of Oceanology and Limnology, 2019, 37(5): 1678-1685. DOI： 10.1007/s00343-019-8196-8.

摘要

Abstract

Phycocyanin (PC)

a natural algal protein

is reported for having anti-oxidant and antiinflammatory properties. We investigated its ability to attenuate lung inflammation in mice subjected to X-ray radiation. Male C57BL/6 mice were assigned to the control

total body irradiation

PC pretreatment

and PC treatment groups. Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation

and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation. Lungs were collected on Day 7 after irradiation exposure. Hematoxylin and eosin staining of mouse lung sections showed considerable inflammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group. Pretreatment or treatment with PC significantly decreased levels of interleukin-6 and tumor necrosis factor-α in the lung

and also increased the relative mRNA expression of superoxide dismutase and glutathione. In vivo

PC significantly reduced the expression of Toll-like receptor TLR2

myeloid differentiation primary response Myd88

and nuclear factor NF-κB

at both the transcriptional and translation level. Taken together

these data indicated that PC attenuated lung inflammatory damage induced by radiation by blocking the TLR2-MyD88-NF-κB signaling pathway. Therefore

PC could be a protective agent against radiation-induced inflammatory damage in normal tissues.

关键词

Keywords

references

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