Inhibition of experimental autoimmune orchitis by fossil diatoms

Oscar D. Bustuoabad; Roberto P. Meiss; Alfredo R. Molinolo; Alejandro M. S. Mayer

doi:10.1007/BF02852899

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Inhibition of experimental autoimmune orchitis by fossil diatoms

OriginalPaper | Updated：2023-05-16

- Inhibition of experimental autoimmune orchitis by fossil diatoms
- Inhibition of experimental autoimmune orchitis by fossil diatoms
- 海洋湖沼学报（英文） 1985年3卷第1期页码：23-29
- Affiliations：
  
  1. PLEX-CONICET Instituto de Investigaciones Hematológicas Academia Nacional de Medicina
  2. Centro de Estudios Oncológicos Academia Nacional de Medicina
- Author bio：
- Funds：
- DOI：10.1007/BF02852899
  中图分类号：
- 纸质出版：1985
- Accepted：
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Inhibition of experimental autoimmune orchitis by fossil diatoms[J]. 海洋湖沼学报（英文）, 1985,3(1):23-29.

Bustuoabad, O.D., Meiss, R.P., Molinolo, A.R. et al. Inhibition of experimental autoimmune orchitis by fossil diatoms., Chin. J. Ocean. Limnol. 3, 23–29 (1985). https://doi.org/10.1007/BF02852899
Inhibition of experimental autoimmune orchitis by fossil diatoms[J]. 海洋湖沼学报（英文）, 1985,3(1):23-29. DOI： 10.1007/BF02852899.

Bustuoabad, O.D., Meiss, R.P., Molinolo, A.R. et al. Inhibition of experimental autoimmune orchitis by fossil diatoms., Chin. J. Ocean. Limnol. 3, 23–29 (1985). https://doi.org/10.1007/BF02852899 DOI：

摘要

Abstract

Experimental autoimmune orchitis (EAO) induced in Swiss mice could be reduced by means of the utilization of micronized frustules of fossil diatoms (DS) containing 54% of SiO2. Experimental mice were sensitized with testicular Antigen (Ag) in Complete Freund’s Adjuvant (CFA) inoculated twice

on day 0 and day 21. 100 μg of DS suspension was inoculated into sensitized mice 10 times

once every 4 days

subcutaneously

starting on day 7 after the first Ag inoculation. Mice receiving the DS treatment showed a diminution of the delayed hypersensitivity reaction

lower antibody titer and decreased incidence of testicular injury as well as reduced grade and extension of the lesions. Possible explanation of these results would suggest alteration of monocyte and/or macrophage normal behaviour as well as alteration of antibody synthesis by different mechanisms.

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references

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