Effect of fossil diatoms on the growth of two syngeneic murine leukemias

Oscar D. Bustuoabad; Alejandro M. S. Mayer

doi:10.1007/BF02851487

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Effect of fossil diatoms on the growth of two syngeneic murine leukemias

OriginalPaper | Updated：2023-05-16

- Effect of fossil diatoms on the growth of two syngeneic murine leukemias
- Effect of fossil diatoms on the growth of two syngeneic murine leukemias
- 海洋湖沼学报（英文） 1984年2卷第2期页码：161-167
- Affiliations：
  
  Plex-Conicet Instituto de Investigaciones Hematológicas Academia Nacional de Medicina
- Author bio：
- Funds：
- DOI：10.1007/BF02851487
  中图分类号：
- 纸质出版：1984
- Accepted：
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Effect of fossil diatoms on the growth of two syngeneic murine leukemias[J]. 海洋湖沼学报（英文）, 1984,2(2):161-167.

Bustuoabad, O.D., Mayer, A.M.S. Effect of fossil diatoms on the growth of two syngeneic murine leukemias., Chin. J. Ocean. Limnol. 2, 161–167 (1984). https://doi.org/10.1007/BF02851487
Effect of fossil diatoms on the growth of two syngeneic murine leukemias[J]. 海洋湖沼学报（英文）, 1984,2(2):161-167. DOI： 10.1007/BF02851487.

Bustuoabad, O.D., Mayer, A.M.S. Effect of fossil diatoms on the growth of two syngeneic murine leukemias., Chin. J. Ocean. Limnol. 2, 161–167 (1984). https://doi.org/10.1007/BF02851487 DOI：

摘要

Abstract

The effect of micronized frustules of fossil diatoms (DS) on tumor growth and survival of mice receiving an ip inoculations of either a spontaneous lymphoblastic leukemia (LB) or P-388 lymphocytic leukemia (P-388) was investigated. A multi-dose study was designed

mice receiving 1000

100

10 and 1 μg of a suspension of DS

either ip or sc on day 1

4 and 9 after tumor inoculation. With LB the best results were observed when DS were inoculated by the ip route

no effect being observed with the sc route. The best therapeutic effect resulted with 1 μg DS: 33% of the mice were alive 24 days after tumor inoculation

when all the controls had died. With P-388

only a temporary effect with the 10 μg DS dose was observed. In no case was it possible to prolong survival. It is concluded that at low doses of DS therapeutic effect is greatest

while toxicity due to SiO2 is greatly reduced.

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references

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