<italic style="font-style: italic">β</italic>-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in <italic style="font-style: italic">Pseudomonas aeruginosa</italic>

Yuqi GUO; Youmin YING; Qihao WU; Bin WEI; Jianwei CHEN; Hong WANG

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β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa

Biology | Updated：2024-10-12

- β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa
- β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa
- 海洋湖沼学报(英文) 2023年41卷第3期页码：1159-1167
- Affiliations：
  
  College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, China
- Author bio：
  
  cjw983617@zjut.edu.cn
  hongw@zjut.edu.cn
- Funds：
- DOI：
  中图分类号：
- 收稿：2022-01-08，
  
  纸质出版：2023-05-01
- Accepted：
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β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa[J]. 海洋湖沼学报(英文), 2023,41(3):1159-1167.

GUO Yuqi,YING Youmin,WU Qihao,et al.,β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in ,Pseudomonas aeruginosa[J].Journal of Oceanology and Limnology,2023,41(03):1159-1167.
β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa[J]. 海洋湖沼学报(英文), 2023,41(3):1159-1167. DOI：

GUO Yuqi,YING Youmin,WU Qihao,et al.,β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in ,Pseudomonas aeruginosa[J].Journal of Oceanology and Limnology,2023,41(03):1159-1167. DOI：

摘要

Abstract

This chemical study reports a novel siderophore-like compound

-cyclopiazonic acid (

-CPA) extracted from marine fungus

Aspergillus flavus

. The chemical structure of

-CPA was elucidated by a combination of extensive spectroscopic analyses and TDDFT-ECD calculations. The iron-binding ability and CAS assays demonstrate that

-CPA is a novel siderophore that features a different chemical structure from those of traditional siderophores. The

-CPA has no obvious influence on the growth of bacterium

Pseudomonas aeruginosa

PAO1. However

its iron chelator could promote the growth of

aeruginosa

PAO1

suggesting that

aeruginosa

employed siderophores to sequester iron

which is vital for their survival. The study provides the physiochemical evaluation of

-CPA

an unusual skeleton-structure siderophore

which for the first time

was proven to have the ability to bind iron and affect

aeruginosa

growth. This new discovery of siderophore provides an opportunity for developing novel anti-

aeruginosa

drugs.

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Keywords

references

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β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa

β-cyclopiazonic acid binds iron demonstrating siderophore-like activity and promotes growth in Pseudomonas aeruginosa

DOI：

摘要

Abstract

关键词

Keywords

references