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Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete
Streptomyces diastaticus NBU2966- Journal of Oceanology and Limnology Vol. 42, Issue 6, Pages: 1991-1997(2024)
- Affiliations：
1.Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo315211, China
2.Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou318053, China
3.School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou310014, China
4.Ningbo Institute of Marine Medicine, Peking University, Ningbo315800, China
- Author bio：
heshan@nbu.edu.cn
dinglijian@nbu.edu.cn
- Funds：
DOI：10.1007/s00343-024-3195-9
CLC：Received：17 October 2023，
Published：01 November 2024
- Accepted：
Scan QR Code
TAN Shuangling,LIU Yang,FU Haonan,et al.Research Paper Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete ,Streptomyces diastaticus NBU2966[J].Journal of Oceanology and Limnology,2024,42(06):1991-1997.
TAN Shuangling,LIU Yang,FU Haonan,et al.Research Paper Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete ,Streptomyces diastaticus NBU2966[J].Journal of Oceanology and Limnology,2024,42(06):1991-1997. DOI： 10.1007/s00343-024-3195-9.
摘要
Abstract
Marine natural products offer a promising source in the development of new antibiotic drugs. Two previously undescribed compounds
including one sulfur-bearing alkaloid named quinosumycin (
1
) along with one chromone derivative namely chromycone (
2
)
were discovered from an ethyl acetate (EtOAc) extract of marine
Streptomyces diastaticus
NBU2966 through a bioactivity-guided isolation prioritized for antimicrobial potential. The analysis of nuclear magnetic resonance (NMR) spectroscopy
high resolution electrospray ionization mass spectroscopy (HRESIMS) data
and electronic circular dichroism (ECD) calculations enabled the elucidation of their structures and the determination of their absolute configurations. Quinosumycin (
1
) is the first heterodimer scaffold incorporating quinolinone and quinazolinone motifs coupled by a thioether bond. Interestingly
Compound
1
exhibited a relatively selective growth inhibition against methicillin-resistant
Staphylococcus aureus
(MRSA) with the minimal inhibitory concentration (MIC) value of 8 μg/mL.
关键词
Keywords
references
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