Structural characterization of sulfated galactofucan from <italic style="font-style: italic">Undaria pinnatifida</italic> and its effect on type 2 diabetic mice

Songze KE; Bo ZHANG; Yanlei YU; Sijia WANG; Weihua JIN; Jian WU; Jianwei CHEN; Huawei ZHANG; Bin WEI; Hong WANG

doi:10.1007/s00343-021-1307-3

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Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

Biology | Updated：2023-04-27

- Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice
- Journal of Oceanology and Limnology Vol. 41, Issue 1, Pages: 300-313(2023)
- Affiliations：
  
  1.College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Moganshan Research Institute at Deqing County Zhejiang University of Technology, Zhejiang University of Technology, Hangzhou 310014, China
  2.Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles CA 90024, USA
  3.College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
  4.Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China
  5.Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou 310014, China
- Author bio：
  
  Bin WEI, E-mail: binwei@zjut.edu.cn
  Hong WANG, E-mail: hongw@zjut.edu.cn
- Funds：
- DOI：10.1007/s00343-021-1307-3
  CLC：
- Received：19 September 2021，
  
  Accepted：01 November 2021，
  
  Online First：27 December 2021，
  
  Published：2023-01
- Accepted：
Scan QR Code
Songze KE, Bo ZHANG, Yanlei YU, et al. Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice[J]. Journal of Oceanology and Limnology, 2023, 41(1): 300-313.
DOI：

Songze KE, Bo ZHANG, Yanlei YU, et al. Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice[J]. Journal of Oceanology and Limnology, 2023, 41(1): 300-313. DOI： 10.1007/s00343-021-1307-3.

摘要

Abstract

A sulfated galactofucan designated as UpG was obtained from the brown algae

Undaria pinnatifida

by calcium chloride extraction. Chemical analyses showed that UpG is composed of galactose and fucose at a high sulfation level. Low-molecular weight UpGP-0.5 was prepared from UpG through acid hydrolysis for structure characterization. The backbones of UpG are determined to be α-(1

3)-Fuc

α-(1

4)-Gal

α-(1

3)-Gal

and α-(1

6)-Gal by GC-MS

FT-IR

NMR

and LC-MS analyses. Sulfate groups are modified at C2 and/or C4 of fucose and C3 and/or C4 of galactose. UpG could partially lower blood sugar and serum lipid levels in type 2 diabetic mice. Moreover

UpG treatment regulates the abundance of some specific gut microbiota

such as enriching the abundance of

Muribaculum

and Christensenellaceae

and reducing that of

Bilophila

Tannerellaceae

Candidatus Saccharimonas

and

Anaerotruncus

. The findings characterized the detailed structure of a sulfated galactofucan and investigated its potential for the treatment of type 2 diabetes mellitus.

关键词

Keywords

references

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Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

DOI：10.1007/s00343-021-1307-3

摘要

Abstract

关键词

Keywords

references