The role of Smad6 in immunity of the pearl oyster <italic style="font-style: italic">Pinctada fucata martensii</italic>

Yu SHI; Xiaolan PAN; Meng XU; Huiru LIU; Hanzhi XU; Maoxian HE

doi:10.1007/s00343-021-1088-8

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The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii

Biology | Updated：2023-05-20

- The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii
- Journal of Oceanology and Limnology Vol. 40, Issue 3, Pages: 1135-1147(2022)
- Affiliations：
  
  1.CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
  2.Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China
- Author bio：
  
  Maoxian HE, hmx2@scsio.ac.cn
- Funds：
- DOI：10.1007/s00343-021-1088-8
  CLC：
- Published：2022-03
- Accepted：
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Yu SHI, Xiaolan PAN, Meng XU, et al. The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii[J]. Journal of Oceanology and Limnology, 2022, 40(3): 1135-1147.
DOI：

Yu SHI, Xiaolan PAN, Meng XU, et al. The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii[J]. Journal of Oceanology and Limnology, 2022, 40(3): 1135-1147. DOI： 10.1007/s00343-021-1088-8.

摘要

Abstract

Inhibitory Smads (I-Smads)

which belong to the Smad family and inhibit bone morphogenic protein 2 (BMP2) signaling by a variety of mechanisms

can suppress innate immunity responses in vertebrates. However

there are no reports for the role of Smad6 in immunity in mollusks. In this study

we showed that Smad6 of the pearl oyster

Pinctada fucata martensii

was located in the Smad6 cluster of the phylogenetic tree; mRNA expression of

Smad6

and

Smad3

was up-regulated after lipopolysaccharide and polyinosinic: polycytidylic challenge; and transcript levels of

Smad6

and

Smad3

showed opposite patterns during wound healing. Under salinity stress

water inflow and outflow in the gills appear to be regulated by BMP2-Smads signals

and BMP2-Smads signaling may be closely related to the immune response. Our results indicate that Smad6 is involved in immunity

that it plays a positive role in the response to immune challenge and an inhibitory role during wound healing

and that Smad6 and Smad3 may work against each other.

关键词

Keywords

references

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The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii

DOI：10.1007/s00343-021-1088-8

摘要

Abstract

关键词

Keywords

references