<italic style="font-style: italic">Pyropia haitanensis</italic> polysaccharide extends lifespan by inhibiting protein aggregation in <italic style="font-style: italic">Caenorhabditis elegans</italic>

Zhongshan ZHANG; Xiaomei WANG; Yongliang PAN; Zhanqi WANG; Zhengshun WEN; Feng LIU; Genxiang MAO

doi:10.1007/s00343-020-0088-4

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Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans

Biology | Updated：2023-06-06

- Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
- Journal of Oceanology and Limnology Vol. 39, Issue 2, Pages: 705-713(2021)
- Affiliations：
  
  1.Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou Central Hospital, Huzhou 313000, China
  2.Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan 316022, China
  3.CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
  4.Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China
- Author bio：
  
  Zhongshan ZHANG, E-mail: 01959@zjhu.edu.cn
- Funds：
- DOI：10.1007/s00343-020-0088-4
  CLC：
- Received：14 February 2020，
  
  Accepted：13 April 2020，
  
  Online First：03 May 2020，
  
  Published：2021-03
- Accepted：
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Zhongshan ZHANG, Xiaomei WANG, Yongliang PAN, et al. Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans[J]. Journal of Oceanology and Limnology, 2021, 39(2): 705-713.
DOI：

Zhongshan ZHANG, Xiaomei WANG, Yongliang PAN, et al. Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans[J]. Journal of Oceanology and Limnology, 2021, 39(2): 705-713. DOI： 10.1007/s00343-020-0088-4.

摘要

Abstract

Pyropia haitanensis

polysaccharide (LP) have been found for having many excellent functions such as anti-aging. Using

Caenorhabditis elegans

models

we evaluated the anti-aging activity of LP by observing the lifespan

reproduction

pharyngeal pumping

stress response

quantitative fluorescence of polyglutamic acid

and nuclear localization of DAF-16 of worms. The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes

indicating a connection of its anti-aging benefit with the toxicity-suppressing effect. The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39% (

0.05) to the control. The high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control (

0.001). Therefore

we believe that LP could extend the lifespan and reduce the protein aggregation in

C. elegans

through nuclear DAF-16:: GFP expression.

关键词

Keywords

references

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Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans

DOI：10.1007/s00343-020-0088-4

摘要

Abstract

关键词

Keywords

references