A new acyclic peroxide from <italic style="font-style: italic">Aspergillus nidulans</italic> SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

Fengyi LÜ; Xiaoming LI; Luping CHI; Linghong MENG; Bingui WANG

doi:10.1007/s00343-020-0052-3

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A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

Chemistry | Updated：2023-04-27

- A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea
- Journal of Oceanology and Limnology Vol. 38, Issue 4, Pages: 1225-1232(2020)
- Affiliations：
  
  1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
  2.College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China
  3.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
- Author bio：
  
  WANG Bingui, wangbg@qdio.ac.cn
- Funds：
- DOI：10.1007/s00343-020-0052-3
  CLC：
- Received：19 January 2020，
  
  Accepted：03 March 2020，
  
  Online First：16 April 2020，
  
  Published：2020-07
- Accepted：
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Fengyi LÜ, Xiaoming LI, Luping CHI, et al. A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. Journal of Oceanology and Limnology, 2020, 38(4): 1225-1232.
DOI：

Fengyi LÜ, Xiaoming LI, Luping CHI, et al. A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. Journal of Oceanology and Limnology, 2020, 38(4): 1225-1232. DOI： 10.1007/s00343-020-0052-3.

摘要

Abstract

A new acyclic peroxide derivative asperoxide A (

)

along with 13 known compounds

namely

microperfuranone (

)

9-hydroxymicroperfuranone (

)

gibellulin A (

)

lecanoric acid (

)

terrequinone A (

)

sterigmatocystin (

)

isosecosterigmatocystin (

)

arugosin C (

)

curvularin (

)

3'-diindolylmethane (

)

austinol (

)

austin (

)

and dehydroaustin (

)

were isolated and identified from the culture extract of

Aspergillus nidulans

SD-531

a fungus obtained from the deep-sea sediment of cold spring in the South China Sea. Their structures were determined based on detailed interpretation of nuclear magnetic resonance (NMR) spectroscopic and mass spectrometry data analysis. All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi. Compounds

and

exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration (MIC) values ranging from 2 to 64 ǌg/mL. Compounds

and

displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents.

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Keywords

references

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Related Author

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Related Institution

CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences

College of Marine Science, University of Chinese Academy of Sciences

Laboratory of Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology

Center for Ocean Mega-Science, Chinese Academy of Sciences

Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences

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A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

DOI：10.1007/s00343-020-0052-3

摘要

Abstract

关键词

Keywords

references