Preparation, characterization, and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives

Jun ZHU; Song LIU; Yukun QIN; Rong'e XING; Huahua YU; Xiaolin CHEN; Pengcheng LI

doi:10.1007/s00343-019-9099-4

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Preparation, characterization, and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives

Biology | Updated：2023-05-19

- Preparation, characterization, and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives
- Journal of Oceanology and Limnology Vol. 38, Issue 3, Pages: 841-850(2020)
- Affiliations：
  
  1.Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
  2.Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology(Qingdao), Qingdao 266237, China
  3.University of Chinese Academy of Sciences, Beijing 100049, China
- Author bio：
  
  LIU Song, sliu@qdio.ac.cn
  LI Pengcheng, pcli@qdio.ac.cn
- Funds：
- DOI：10.1007/s00343-019-9099-4
  CLC：
- Received：10 April 2019，
  
  Accepted：22 August 2019，
  
  Online First：23 September 2019，
  
  Published：2020-05
- Accepted：
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Jun ZHU, Song LIU, Yukun QIN, et al. Preparation, characterization, and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives[J]. Journal of Oceanology and Limnology, 2020, 38(3): 841-850.
DOI：

Jun ZHU, Song LIU, Yukun QIN, et al. Preparation, characterization, and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives[J]. Journal of Oceanology and Limnology, 2020, 38(3): 841-850. DOI： 10.1007/s00343-019-9099-4.

摘要

Abstract

Phytopathogenic fungi cause heavy negative impact on the agricultural economy

but most existing fungicides are toxic and pose a threat to both human health and environments. A green and efficient fungicide is urgently needed. Chitooligosaccharides (COSs)

the degradation products of natural polysaccharide chitosan

are nontoxic and biodegradable antifungal substances. In this study

a novel type of aminourea chitooligosaccharide derivatives (AUCOS) was synthesized by successively grafting a hydrazine group and an amine-carbonyl group onto a chitooligosaccharide backbone to enhance the antifungal capability of COSs. The structures of the target compounds were identified by FTIR

H NMR

and

C NMR

and the degree of substitution of each product was calculated from the results of the elemental analysis. The antifungal activities of the prepared chitooligosaccharide derivatives against

Fusarium solani

Verticillium albo

atrum

and

Phytophthora capsici

were tested in vitro. The AUCOSs had better inhibitory efficiencies against the three plant pathogen fungi than that of chitooligosaccharide

of which aminourea chitooligosaccharide 2 (AUCOS2) was the most promising antifungal compound

whose highest inhibition rates were 60.12%

82.95%

and 85.23% against

solani

albo

atrum

and

capsici

respectively. The synthesized derivatives have good application prospects in crop protection and deserve further research.

关键词

Keywords

references

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