Effects of florfenicol exposure on growth, development and antioxidant capacity of flounder <italic style="font-style: italic">Paralichthys olivaceus</italic> larvae at different developmental stages

Rui GUO; Yingqi ZHANG; Xianyu ZHANG; Qian ZHANG; Rui CHENG; Rahman MD MOSTAFIZUR; Ying LIU

doi:10.1007/s00343-019-9023-y

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Effects of florfenicol exposure on growth, development and antioxidant capacity of flounder Paralichthys olivaceus larvae at different developmental stages

Aquaculture and Fisheries | Updated：2023-04-27

- Effects of florfenicol exposure on growth, development and antioxidant capacity of flounder Paralichthys olivaceus larvae at different developmental stages
- Journal of Oceanology and Limnology Vol. 38, Issue 2, Pages: 550-559(2020)
- Affiliations：
  
  1.College of Marine Science and Environment, Dalian Ocean University, Dalian 116023, China
  2.Liaoning Aquacultural Engineering R&D Center, Dalian 116023, China
- Author bio：
  
  ZHANG Qian, E-mail:qianzhang@dlou.edu.cn
- Funds：
- DOI：10.1007/s00343-019-9023-y
  CLC：
- Received：24 January 2019，
  
  Accepted：24 April 2019，
  
  Online First：02 July 2019，
  
  Published：2020-03
- Accepted：
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Rui GUO, Yingqi ZHANG, Xianyu ZHANG, et al. Effects of florfenicol exposure on growth, development and antioxidant capacity of flounder Paralichthys olivaceus larvae at different developmental stages[J]. Journal of Oceanology and Limnology, 2020, 38(2): 550-559.
DOI：

Rui GUO, Yingqi ZHANG, Xianyu ZHANG, et al. Effects of florfenicol exposure on growth, development and antioxidant capacity of flounder Paralichthys olivaceus larvae at different developmental stages[J]. Journal of Oceanology and Limnology, 2020, 38(2): 550-559. DOI： 10.1007/s00343-019-9023-y.

摘要

Abstract

Antibiotics are widespread in various environmental media

and may pose a potential threat to aquatic ecosystems and non-target aquatic organisms. Florfenicol (FLO) is one of the most commonly used antibiotics in aquaculture

and extensively used to substitute chloramphenicol with its strong sterilization and low adverse effect. In this study

flounder

Paralichthys olivaceus

an important economic fish species in seawater was used as an experimental subject. Five exposure concentrations of FLO (including environmentrelated concentrations) were set at 0

0.01

0.1

and 10 mg/L. Effects of FLO exposure for 168 h on growth and development

motor behavior

antioxidant enzyme activity

malondialdehyde (MDA) content

and thyroid hormone level of

P. olivaceus

larvae were studied in pre-larvae (1 dpf) and post-larvae (20 dpf). The results show that the short-term FLO exposure could promote the larvae growth to some degrees

but inhibit them as the exposure time prolonged. For pre-larvae

FLO at 0.01 mg/L could stimulate the motor nerve system and increase the swimming ability

but inhibited it at 1 mg/L. With the increasing dosage of FLO

the superoxide dismutase (SOD) and MDA contents were elevated

reaching the maximum in the 1 mg/L FLO group. The pre-larvae were more sensitive than the post-larvae to FLO in the environment

and the growth and immune resistance could be damaged with long exposure. Post-larvae were more tolerant to external pollutants

FLO at 1 mg/L could promote the motor behavior and reduce SOD and MDA contents. Therefore

FLO can be used as an antibiotic at a proper concentration but as a drug to prevent disease in a long-term way.

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Effects of florfenicol exposure on growth, development and antioxidant capacity of flounder Paralichthys olivaceus larvae at different developmental stages

DOI：10.1007/s00343-019-9023-y

摘要

Abstract

关键词

Keywords

references