A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus <italic style="font-style: italic">Chaetomium globosum</italic> YP-106

Yaqin FAN; Chunjiao JIANG; Peihai LI; Cong WANG; Hao CHEN

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A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106

Biology | Updated：2024-10-12

- A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106
- Journal of Oceanology and Limnology Vol. 41, Issue 3, Pages: 1145-1151(2023)
- Affiliations：
  
  1.MNR Key Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China
  2.Shandong Provincial Key Laboratory of Applied Mycology, School of Life Sciences, Qingdao Agricultural University, Qingdao 266109, China
  3.Engineering Research Center of Zebra fish Models for Human Diseases and Drug Screening of Shandong Province, Shandong Provincial Engineering Laboratory for Biological Testing Technology, Key Laboratory for Biosensor of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China
  4.Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
- Author bio：
  
  ** wangcong123206@163.com;
  hchen@fio.org.cn
- Funds：
- DOI：
  CLC：
- Received：22 January 2022，
  
  Revised：2022-03-04，
  
  Accepted：08 March 2022，
  
  Published：2023
- Accepted：
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Yaqin FAN, Chunjiao JIANG, Peihai LI, et al. A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106[J]. Journal of Oceanology and Limnology, 2023, 41(3): 1145-1151.
DOI：

Yaqin FAN, Chunjiao JIANG, Peihai LI, et al. A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106[J]. Journal of Oceanology and Limnology, 2023, 41(3): 1145-1151. DOI：

摘要

Abstract

A new chloro-azaphilone derivative chaetoviridin L (

) along with four known analogues

namely

chaetomugilin A (

)

chaetoviridin E (

)

chaetomugilin O (

)

and chaephilone D (

)

is isolated and identified from the culture extract of

Chaetomium globosum

YP-106

a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap Trench. Their structures were determined based on detailed interpretation of nuclear magnetic resonance (NMR) spectroscopic

mass spectrometry (MS) data analysis and comparison with the reported literature. The absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish model. Compounds

and

significantly promoted the angiogenesis in a dose-dependent manner and thus

these compounds might be used as promi

sing molecules for the treatment of cardiovascular disease.

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references

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A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106

DOI：

摘要

Abstract

关键词

Keywords

references