Pharmacokinetics of fucoidan and low molecular weight fucoidan from <italic style="font-style: italic">Saccharina</italic><italic style="font-style: italic">japonica</italic> after oral administration to mice

Jiaojiao TAN; Yimin SONG; Jing WANG; Ning WU; Yang YUE; Quanbin ZHANG

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Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharinajaponica after oral administration to mice

Biology | Updated：2024-10-14

- Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharinajaponica after oral administration to mice
- Journal of Oceanology and Limnology Vol. 41, Issue 5, Pages: 1900-1909(2023)
- Affiliations：
  
  1. Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
  2. Laboratory for Marine Biology and Biotechnology, National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China
  3. University of Chinese Academy of Sciences, Beijing 100049, China
  4. Department of Pharmaceutical Engineering, Qingdao University of Science and Technology, Qingdao 266000, China
  5. Laboratory for Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China
  6. Nantong Zhongke Marine Science and Technology Research and Development Center, Nantong 226000, China
- Author bio：
  
  wuning@qdio.ac.cn
  qbzhang@qdio.ac.cn
- Funds：
- DOI：
  CLC：
- Received：25 April 2022，
  
  Accepted：13 July 2022，
  
  Online First：15 August 2022，
  
  Published：01 September 2023
- Accepted：
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TAN Jiaojiao,SONG Yimin,WANG Jing,et al.Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina, japonica after oral administration to mice[J].Journal of Oceanology and Limnology,2023,41(05):1900-1909.
DOI：

TAN Jiaojiao,SONG Yimin,WANG Jing,et al.Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina, japonica after oral administration to mice[J].Journal of Oceanology and Limnology,2023,41(05):1900-1909. DOI：

摘要

Abstract

The brown seaweed

Sacchairna

japonica

has been used in traditional Chinese medicine for over one thousand years. Oral administration of fucoidan or low molecular weight fucoidan (LMWF) from

japonica

could ameliorate kidney dysfunction in chronic kidney diseases and inhibit diabetic vascular complications. In many studies

LMWF was found to be more potent than fucoidan with high molecular weight. However

the pharmacokinetics of LMWF still remains unclear. The purpose of the research is to compare the pharmacokinetics of fucoidan with high molecular weight (136 kDa) with that low molecular weight (9.5 kDa) after oral administration to ICR mice. Since fucose is the main and representative monosaccharide of fucoidans

we evaluate the pharmacokinetics of fucoidan and LMWF by determining the fucose concentration in mice serum. Both fucoidan and LMWF were absorbed following oral administration. Fucoidan and LMWF were provided to mice by oral administration with 60 mg/kg and the maximum Concentration (

max

) was found at 2.5 h (0.66±0.32 mg/L) for Fucoidan and 1.5 h (1.01±0.56 mg/L) for LMWF

respectively. It seems that LMWF had a higher area under the curve (AUC

0–

) and was absorbed more quickly than fucoidan. The estimated bioavailability of LMWF was 28.3% in the mice treated with a

single dose of 30 mg/kg. In addition

LMWF was found widely spreaded into different tissues following oral administration and the highest concentration was found in kidney at 19.93±7.02 μg/g. In this study

we first studied the pharmacokinetics of LMWF

in order to help to understand the function of LMWF. And our results shed light on the potential of development of drugs based on LMWF.

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references

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Related Institution

Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology

University of the Chinese Academy of Sciences

Laboratory for Marine Drugs and Biological Products, Pilot National Laboratory for Marine Science and Technology

Jiangsu Innovation Center of Marine Bioresources, Jiangsu Coast Development Investment Co., Ltd., Jiangsu Coast Development Group Co., Ltd.

Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center

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Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharinajaponica after oral administration to mice

DOI：

摘要

Abstract

关键词

Keywords

references